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Antigenic Specificity | CD163 (Monocyte & Macrophage Marker) |
Clone | [M130/1210] |
Host Species | Mouse |
Reactive Species | human. |
Isotype | IgG2b, kappa |
Format | unconjugated |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Formalin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAb recognizes a protein of 140kDa, identified as CD163. It has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. This receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with anti-CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of anti-CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. Anti-CD163 is of considerable value for selective identificati |
Immunogen | Immunogen: Recombinant human CD163 fragment (around aa 43-196) Cellular Localization: Cell Surface & Cytoplasmic |
Other Names | [CD163, CD163 antigen, Macrophage-associated antigen, M130, CD163 molecule, Hemoglobin scavenger receptor, MM130; Scavenger receptor cysteine rich type 1 protein M130] |
Gene, Accession # | [CD163], Gene ID: 9332, NCBI: NP_004235.4, UniProt: Q86VB7 |
Catalog # | MBS4380519 |
Price | $190, $340, $340 |
Order / More Info | CD163 (Monocyte & Macrophage Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Sean K. Lau, Peiguo G. Chu, and Lawrence M. Weiss. CD163: A Specific Marker of Macrophages in Paraffin-Embedded Tissue Samples Am J Clin Pathol 2004; 122:794-801. |