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Antigenic Specificity | PINK1 (E417G Mutant) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunoaffinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Synthetic peptide derived from a mutant form of the human PINK1 protein Background: Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fl |
Immunogen | Immunogen: Synthetic peptide derived from a mutant form of the human PINK1 protein |
Other Names | [PINK1; PINK1; PINK1], [UNQ740] |
Gene, Accession # | [PINK1], NCBI: AAQ89316.1 |
Catalog # | MBS396697 |
Price | $340 |
Order / More Info | PINK1 (E417G Mutant) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |