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Antigenic Specificity | Paxillin |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human, rat, mouse, chicken |
Isotype | IgG1 |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot, Immunocytochemistry, Immunoprecipitation |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects a 68kDa* protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells. Similar results were seen in various cells and tissues from rat, mouse, and chicken origin. Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at both tyrosine and serine sites. Serine phosphorylation of paxillin occurs in response to growth-factor activation and fibronectins. Both JNK1 and cdc2 kinases can phosphorylate ser |
Immunogen | Immunogen: Clone (M107) was generated from full-length recombinant human paxillin. |
Other Names | [Paxillin; Paxillin], [Pxn; Pxn; Pxn] |
Gene, Accession # | Gene ID: 360820, NCBI: NP_001012147.1, UniProt: Q66H76 |
Catalog # | MBS470022 |
Price | $325 |
Order / More Info | Paxillin Antibody from MYBIOSOURCE INC. |
Product Specific References | • Huang, C. et al. (2003) Nature 424:219-223.• Huang, C. et al. (2004) Cell Cycle 3(1):4-6.• Woodrow, M.A. (2003) Exp. Cell. Res. 287(2):325-338. |