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Antigenic Specificity | HIF1AN |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 2.7mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm. |
Immunogen | Immunogen: Synthetic peptide of human HIF1AN Calculated Molecular Weight: 40kDa |
Other Names | [FIH1] |
Gene, Accession # | [HIF1AN], Gene ID: 55662, NCBI: Q9NWT6.2 |
Catalog # | MBS2518439 |
Price | $110, $150, $225 |
Order / More Info | HIF1AN Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |