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Antigenic Specificity | PARP1 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: PARP1 Antibody detects endogenous levels of total PARP1. PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2, 3) and is one of the main cleavage targets of caspase-3 in vivo (4, 5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2, 4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6). |
Immunogen | Immunogen: Recombinant protein of human PARP1 |
Other Names | [ADPRT; ADPRT1; PARP; PARP-1; PPOL; pADPRT-1] |
Gene, Accession # | [PARP1], Gene ID: 142, NCBI: NP_001609.2, UniProt: P09874 |
Catalog # | MBS8516640 |
Price | $290 |
Order / More Info | PARP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |