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Antigenic Specificity | CD42c |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plate |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthetic peptide contain a sequence corresponding to a region within amino acids 56 and 118 of Human GP1BB |
Other Names | [platelet glycoprotein Ib beta chain; Platelet glycoprotein Ib beta chain; platelet glycoprotein Ib beta chain; glycoprotein Ib (platelet), beta polypeptide; Antigen CD42b-beta; CD_antigen: CD42c] |
Gene, Accession # | [CD42c], Gene ID: 2812, NCBI: NP_000398 |
Catalog # | MBS9404318 |
Price | $320 |
Order / More Info | CD42c Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |