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Antigenic Specificity | CD27 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human. |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for CD27 antigen (CD27) detection. Background: CD27 is a member of the tumor necrosis factor receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. And this receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. |
Immunogen | Immunogen: E Coli-derived human CD27 recombinant protein (Position: A20-R191). Human CD27 shares 62.8% amino acid (aa) sequence identity with mouse CD27. |
Other Names | [CD 27; CD27; CD27 antigen; CD27 molecule; CD27L receptor; LPFS2; S152; T14; TNFRSF 7; TNFRSF7; TNFSF7; Tp 55; Tp55; P26842; CD27 antigen; CD27 molecule], [CD27; CD27; T14; S152; Tp55; TNFRSF7; S152. LPFS2; TNFRSF7] |
Gene, Accession # | [CD27], Gene ID: 939, NCBI: NP_001233.1, UniProt: P26842 |
Catalog # | MBS178431 |
Price | $315 |
Order / More Info | CD27 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Entrez Gene: CD27 CD27 molecule.2. Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jun 1997). CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6346-51.3. Yamamoto H, Kishimoto T, Minamoto S (Nov 1998). NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27. Journal of Immunology 161 (9): 4753-9. |