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Antigenic Specificity | Coilin |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Coilin antibody detects endogenous levels of Coilin. Function: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs.Subunit Structure: Interacts with ANKS1B. Interacts with SMN (via Tudor domain). Interacts (via C-terminus) with AK6.Post-translational Modifications: Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs. Phosphorylation during mitosis is associated with disassembly of CBs.Similarity: The atypical Tudor domain at the C-terminus contains two large unstructured loops, and does not bind methylated residues. Belongs to t |
Immunogen | Immunogen: A synthesized peptide derived from human Coilin. Subcellular Location: Nucleus. Nuclear coiled body located in the interchromatin space between the nucleolus and the nucleus. Tissue Specificity: Found in all the cell types examined. |
Other Names | [CLN 80; CLN80; COIL; COIL_HUMAN; Coilin; Coilin p80; p80; P80 coilin] |
Gene, Accession # | [COIL], Gene ID: 8161, NCBI: NP_004636.1, UniProt: P38432 |
Catalog # | MBS9603377 |
Price | $240, $280 |
Order / More Info | Coilin Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |