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Antigenic Specificity | EPS8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhib |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human EPS8 (NP 004438.3). |
Other Names | [DFNB102] |
Gene, Accession # | [EPS8], Gene ID: 2059, NCBI: NP_004438, UniProt: Q12929 |
Catalog # | MBS8549579 |
Price | $280 |
Order / More Info | EPS8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |