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Antigenic Specificity | GRP78 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.1 mL |
Concentration | 100ug/100ul |
Applications | Peptide ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GRP78 Bip antibody detects endogenous levels of GRP78 Bip protein. Not tested with other proteins. When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.[supplied by OMIM] |
Immunogen | Immunogen: Synthetic peptide conjugated to KLH |
Other Names | [GRP78 Bip], [HSPA5; HSPA5; BIP; MIF2; GRP78; HEL-S-89n] |
Gene, Accession # | [GRP78], Gene ID: 3309, NCBI: AAA52614.1 |
Catalog # | MBS415427 |
Price | $230 |
Order / More Info | GRP78 Antibody from MYBIOSOURCE INC. |
Product Specific References | Hegde,N.R., Chevalier,M.S., Wisner,T.W et,al The role of BiP in endoplasmic reticulum-associated degradation of major histocompatibility complex class I heavy chain induced by cytomegalovirus proteins |