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Antigenic Specificity | Occludin (Marker of Early Blood Brain Barrier Damage) |
Clone | [OCLN/2181] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA & Azide at 1mg/ml) |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Occludin is a tetraspan integral membrane protein in epithelial and endothelial tight junction (TJ) structures that can contain two extracellular loops. The protein exists in a variety of phosphorylated forms. Phosphorylation is involved in regulating both the localization and the function of Occludin. Expression of Occludin is upregulated by polyunsaturated fatty acids, increasing trans-endothelial cell resistance and reducing cellular permeability to large molecules. The level of Occludin varies greatly depending on tissue; in brain tissue, Occludin is highly expressed at cell-cell contact sites. Non-neural tissues show lower expression and discontinuous distribution. Occludin is a tight junction protein that is a key structu |
Immunogen | Immunogen: Recombinant fragment of human Occludin protein (around aa 282-415) (exact sequence is proprietary) |
Other Names | [BLCPMG; Occludin; OCLN; Phosphatase 1 regulatory subunit 115; PTORCH1; Tight junction protein occludin] |
Gene, Accession # | [OCLN], Gene ID: 100506658, NCBI: NP_001192184.1, UniProt: Q16625 |
Catalog # | MBS4380766 |
Price | $190, $340, $340 |
Order / More Info | Occludin (Marker of Early Blood Brain Barrier Damage) Antibody from MYBIOSOURCE INC. |
Product Specific References | Pan, R. et al. Blood Occludin Level as a Potential Biomarker for Early Blood Brain Barrier Damage Following Ischemic Stroke. Sci. Rep. 7, 40331; (2017) |