NUMB Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | NUMB |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for Protein numb homolog(NUMB) detection. Tested with WB in Human;Mouse. Background: Protein numb homolog is a protein that in humans is encoded by the NUMB gene. It is mapped to 14q24.2 to q24.3. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. The primary function of Numb in cell differentiation is as an inhibitor of Notch signaling which is essential for maintaining self-renewal potential in stem and progenitor cells. Numb also plays a crucial role in asymmetrical cell division during development, allowing for differential cell fate specification in the central a |
| Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human NUMB(194-220aa SFRVTTATEQAEREEIMKQMQDAKKAE), different from the related mouse and rat sequences by one amino acid. Ig Type: Rabbit IgG |
| Other Names | [Protein numb homolog; c14_5527; C14orf41; FLJ31314; h Numb; h-Numb; Numb; Numb homolog (Drosophila); Numb homolog; Numb protein homolog; NUMB_HUMAN; Protein numb homolog; Protein S171; S171; numb homolog (Drosophila)], [NUMB; NUMB; S171; C14orf41; c14_5527; h-Numb] |
| Gene, Accession # | [NUMB], Gene ID: 8650, NCBI: NP_001005743.1, UniProt: P49757 |
| Catalog # | MBS177871 |
| Price | $280 |
| Order / More Info | NUMB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Dho SE, French MB, Woods SA, McGlade CJ (November 1999). Characterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain. J. Biol. Chem. 274 (46): 33097-104. 2. Katoh M, Katoh M (September 2006). NUMB is a break of WNT-Notch signaling cycle. Int. J. Mol. Med. 18(3): 517-21. 3. Pece S, Confalonieri S, R Romano P, Di Fiore PP (January 2011). NUMB-ing down cancer by more than just a NOTCH. Biochim. Biophys. Acta 1815 (1): 26-43. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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