MRCKbeta Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | MRCKbeta |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: MRCKbeta antibody detects endogenous levels of total MRCKbeta. Function: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715, PubMed:21949762). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates PPP1R12A (PubMed:21457715). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is im |
| Immunogen | Immunogen: A synthesized peptide derived from human MRCKbeta Subcellular Location: Cytoplasm. Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Tissue Specificity: Expressed in all tissues examined, with high levels in heart, brain, placenta and lung. Predicted Cross Reactivity: Pig, Zebrafish, Bovine, Horse, Sheep, Dog Similarity: Pig (100%), Zebrafish (82%), Bov |
| Other Names | [CDC42 binding protein kinase beta; CDC42-binding protein kinase beta; CDC42BPB; DMPK like beta; DMPK-like beta; KIAA1124; MRCK beta; MRCKB_HUMAN; Myotonic dystrophy kinase related CDC42 binding kinase beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta; Myotonic dystrophy protein kinase like beta; Myotonic dystrophy protein kinase-like beta; Serine/threonine protein kinase MRCK beta; Serine/threonine-protein kinase MRCK beta] |
| Gene, Accession # | [MRCKbeta], Gene ID: 9578, NCBI: NP_006026.3, UniProt: Q9Y5S2 |
| Catalog # | MBS9602159 |
| Price | $240, $280 |
| Order / More Info | MRCKbeta Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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