AMACR (P504S) clone 13H4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | AMACR (P504S) clone 13H4 |
| Clone | 13H4 |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | ion exchange purified |
| Size | 5 mL |
| Concentration | 4 ug/ml |
| Applications | Immunohistochemistry (IHC) Formalin/Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal Rabbit antibody directed against AMACR (P504S) shows predominant binding to prostate carcinoma tissue and only very faint or no binding to healthy benign prostate or benign prostate hyperplasia. Formaldehyde fixed and paraffin embedded tissue was investigated by Jiang et al. Among a total of 207 tissue samples all 137 carcinoma samples were P504S-positive, independent of Gleason-Score (V->VIII) (Jiang et al., 2001). Thus it may be possible to distinguish tumour epithelial cells from normal epithelial prostate tissue with help of this antibody. The expression of P504S in prostate is inversely related to that of high molecular weight cytokeratins as detected by clone 34betaE12. The majority (82,5%) of atypical adenomatous hyper |
| Immunogen | Immunogen: Human recombinant AMACR (P504S) protein, whole sequence |
| Other Names | [alpha-methylacyl-CoA racemase isoform 3; Alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; alpha-methylacyl-CoA racemase; 2-methylacyl-CoA racemase], [AMACR; AMACR; RM; RACE; CBAS4; P504S; AMACRD] |
| Gene, Accession # | [AMACR], Gene ID: 23600, NCBI: NP_001161067.1, UniProt: Q9UHK6 |
| Catalog # | MBS397452 |
| Price | $735 |
| Order / More Info | AMACR (P504S) clone 13H4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Schmitz W., Albers C., Fingerhut R., and Conzelmann E. (1995) Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. Eur J. Biochem. 231(3); 815-822. 2. Babcook J.S., Leslie K.B., Olsen O.A., et al. (1996) A novel strategy for generating monoclonal antibodies from single isolated lymphocytes producing antibodies of defined specificities. Proc. Natl. Acad. Sci. USA 93; 7843-7848. 3. Xu J., Stolk J.A., Zhang X., et al. (2000) Identificatin of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res. 60; 1677-1682. 4. Ferdinandusse S., Denis S., IJ1st, et al. (2000) Subcellular localization and physiological role of alpha-methylacyl-coA racemase. J. Lipid Res. 41; 1890-1896. 5. Jiang Z., Woda B.A., Rock K.L., Xu Y., Savas L., et al. (2001) P504S a new molecular marker for the detection of prostate carcinoma. Am. J. Surg. Pathol. 25(11): 1397-1404. |
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