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Antigenic Specificity | IRS-2 (Paired S731) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | Size: 100 ug/200 ul |
Applications | ELISA, Western Blot, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~180 kDa of human IRS-2. It also reacts with mouse and rat. The other species are not tested. Insulin Receptor Substrate-2 (IRS-2), a 180kDa cytoplasmic docking protein, is one of the major endogenous substrates of the insulin receptor kinase. The insulin receptor mediates insulin action through the phosphorylation of substrate proteins. The major substrates of the insulin receptor kinase are the insulin receptor substrate (IRS) family of proteins, IRS 1, IRS 2, IRS 3, and IRS 4. IRS 2, a signaling molecule that mediates effects of insulin, Insulin-like growth factor 1 and other cytokines by acting as a molecular adaptor between diverse receptor kinases and downstream effectors. IRS proteins contain more than 70 pot |
Immunogen | Antigen Preparation: A synthetic peptide corresponding to the epitope ASSPA without phosphorylation site Ser 731 of human IRS-2. |
Other Names | [Rabbit IRS-2 (Paired731); Insulin-receptor substrate 2 (IRS-2).], [IRS2; IRS2; IRS-2] |
Gene, Accession # | [IRS-2 (Paired S731)], Gene ID: 8660, NCBI: NP_003740.2, UniProt: Q96RG4 |
Catalog # | MBS462063 |
Price | $285 |
Order / More Info | IRS-2 (Paired S731) Antibody from MYBIOSOURCE INC. |
Product Specific References | Li, Y. et al. (2004) J. Biol. Chem. 279, 45304-45307. |