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Antigenic Specificity | CBLN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CBLN1 antibody detects endogenous levels of total CBLN1. Function: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre-and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre-and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the po |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Secreted. Cell Junction > Synapse > Postsynaptic Cell Membrane. Tissue Specificity: In the Purkinje cells postsynaptic structures. In the cerebellum, cerebellin is much less abundant than [des-Ser1]-cerebellin. Predicted Cross Reactivity: Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus Similarity: Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (100%), Xenopus (91%) |
Other Names | [[des-Ser1]-cerebellin; CBLN 1; CBLN1; CBLN1_HUMAN; CER; Cerebellin 1; Cerebellin 1 precursor; Cerebellin1; Precerebellin] |
Gene, Accession # | [CBLN1], Gene ID: 869, NCBI: NP_004343.1, UniProt: P23435 |
Catalog # | MBS9605379 |
Price | $240, $280 |
Order / More Info | CBLN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |