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Antigenic Specificity | ABL1/2 (phospho-Tyr393/439) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of ABL1/2 only when phosphorylated at tyrosine393/439. Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 393/439 (D-T-Y(p)-T-A) derived from Human ABL1/2. |
Other Names | [Abelson murine leukemia viral oncogene homolog 1; c-ABL; p150] |
Gene, Accession # | [ABL1/2], Gene ID: 25, NCBI: NP_005148.2, UniProt: P00519 |
Catalog # | MBS9400973 |
Price | $200, $255 |
Order / More Info | ABL1/2 (phospho-Tyr393/439) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |