Cyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCyclin D1 (G1-Cyclin & Mantle Cell Marker)
Clone[CCND1/809]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG2a, kappa
Formatphycoerythrin (PE) conjugate
Size0.5 mL
Concentrationn/a
ApplicationsFlow Cytometry (FC/FACS), Immunofluorescence (IF)
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DescriptionRecognizes a protein of 36kDa, identified as cyclin D1. Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. This antibody neutralizes the activity of cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of cyclin D1. This antibody is useful in identifying mantle cell lymphomas (cyclin D1 positive) from CLL/SLL and follicular lymphomas (cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.
ImmunogenImmunogen: Recombinant full-length human CCND1 protein
Other Names[B cell CLL/lymphoma 1, B cell leukemia 1, B-cell lymphoma 1 protein, BCL-1 oncogene, CCND1 protein, CCND1/FSTL3 fusion gene, CCND1/IGHG1 fusion gene CCND1/IGLC1 fusion gene, CCND1/PTH fusion gene, cD1, Cyl 1, G1/S-specific cyclin-D1, Parathyroid adenomatosis 1, PRAD1 oncogene], [CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1]
Gene, Accession #[CCND1], Gene ID: 595, NCBI: NP_444284.1, UniProt: P24385
Catalog #MBS439279
Price$340
Order / More InfoCyclin D1 (G1-Cyclin & Mantle Cell Marker) Antibody from MYBIOSOURCE INC.
Product Specific ReferencesBaldin V; Lukas J; Marcote MJ; Pagano M; Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes and Development, 1993, 7(5):812-21.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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