CML (N-Epsilon)-Carboxymethyl-Lysine Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | CML (N-Epsilon)-Carboxymethyl-Lysine |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.05 mg |
| Concentration | 0.25 mg/ml |
| Applications | Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody is suitable for the detection of CML in tissues and tissue extracts. Long-term incubation of proteins with glucose leads, through Schiff's base and Amadori rearrangement products, to the formation of advanced glycation end products (AGE) which are characterized by fluorescence, brown color and inter- and intra-molecular cross-linking. Recent immunological studies using anti-AGE antibodies demonstrated the presence of AGE in (i) human lens, (ii) renal proximal tubules in patients with diabetic nephropathy and chronic renal failure, (iii) atherosclerotic lesions of arterial walls, (iv) beta2-microglobulin of carpal tunnel amyloid fibril deposits in patients with hemodialysis-related amyloidosis and (v) brain tissues of patients |
| Immunogen | Immunogen: N-Epsilon-(Carboxymethyl)-Lysine (CML)-HSA |
| Other Names | n/a |
| Gene, Accession # | [CML] |
| Catalog # | MBS397107 |
| Price | $1245 |
| Order / More Info | CML (N-Epsilon)-Carboxymethyl-Lysine Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Horiuchi S., Araki N., and Morino Y. (1991) Immunological approach to characterize advanced glycation end products of the Maillard reaction: Evidence for the presence of a common stucture. J. Biol. Chem. 266; 7329-7332. 2. Dunn J.A., Patrick J.S., Thorpe S.R., Baynes J.W. (1989): Oxidation of glycated proteins: age-dependent accumulation of N-epsilon-(carboxymethyl) lysine in lens proteins. Biochemistry. 28: 9464-9468. 3. Fu M.X., Requena J.R., Jenkins A.J., Lions T.J., Baynes J.W., Thorpe S.R. (1996): The advanced glycation end product, N-epsilon-(carboxymethyl) lysine, is a product of both lipid peroxidation and glycoxidation reactions. J.Biol.Chem.271: 9982-9986. |
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MYBIOSOURCE INC.
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