cKit Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | cKit |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | dog, human, monkey, porcine |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 0.55-0.75 ug/ul in antibody stabilization buffer |
| Applications | ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Affinity Purified Tyrosine-protein kinase Kit. Antibody Mid-Region. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activat |
| Immunogen | Immunogen: Synthetic peptide taken within amino acid region 430-480 on human Tyrosine-Kinase c-Kit protein. Immunoglobulin: IgG. Expression: Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells. |
| Other Names | [c-Kit; CD117 antigen; KIT; KIT oncogene; Mast cell growth factor receptor; p145 c-kit; PBT; Piebald trait protein; Proto oncogene c Kit; SCF Receptor; SCFR; soluble KIT variant 1; Steel Factor Receptor; Stem cell factor receptor; Tyrosine-protein kinase Kit; v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein], [KIT; KIT; PBT; SCFR; C-Kit; CD117; SCFR; SCFR; PBT] |
| Gene, Accession # | [cKit], Gene ID: 3815, NCBI: P10721.1, UniProt: P10721 |
| Catalog # | MBS540919 |
| Price | $390 |
| Order / More Info | cKit Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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