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Antigenic Specificity | FceRI, alpha (Fc epsilon RI, IgE Receptor) |
Clone | [0.T.195] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG1,k |
Format | Protein G purified |
Size | 0.2 mg |
Concentration | 1 mg/mL |
Applications | Suitable for use in Immunoprecipitation/Western Blot and FACS. Not suitable for Western Blot without pre-immunoprecipitation of antibody. Other applications have not been tested. |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes rat FceRI alpha at ~45-55kD. The allergic reaction is mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE-FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FceRI receptor is a tetrameric complex, consisting of an a-chain, a b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinas |
Immunogen | Immunogen: Whole rat basophilic leukemia cells, positive for the rat high-affinity receptor recognizing immunoglobulin E (FceRI). |
Other Names | [-FceRI, alpha (Fc epsilon RI, IgE Receptor)], [FCER1A; FCER1A; FCE1A; FcERI; FCE1A; FcERI] |
Gene, Accession # | Gene ID: 2205, NCBI: AAH15195.1, UniProt: P12319 |
Catalog # | MBS632728 |
Price | $630 |
Order / More Info | FceRI, alpha (Fc epsilon RI, IgE Receptor) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |