Edit |   |
---|---|
Antigenic Specificity | TARDBP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total TARDBP protein. TDP43 (TAR DNA-binding protein 43) is involved in transcriptional regulation and exon splicing (1,2). While normal TDP43 is a nuclear protein, pathological TDP43 is a component of insoluble aggregates in patients with frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). In these disorders, TDP43 is abnormally ubiquitinated, phosphorylated and cleaved to generate carboxy-terminal fragments that are sequestered as insoluble aggregates in neuronal nuclei, perikarya, and neurites (3,4). Additionally, TDP43 inhibits the expression of the HIV-1 gene and regulates CFTR gene splicing (1,5). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human TARDBP. |
Other Names | [TARDBP; ALS10; TDP-43; Tdp43; TDP43] |
Gene, Accession # | [TARDBP], Gene ID: 23435, NCBI: NP_031401.1, UniProt: Q13148 |
Catalog # | MBS9402657 |
Price | $255 |
Order / More Info | TARDBP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |