CBLB Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CBLB |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The Casitas B lineage lymphoma (Cbl) proteins (in mammals these are c-Cbl, Cbl-b, and Cbl-c) are a family of single subunit RING finger protein-ubiquitin E3 ligases that contain multiple protein interaction motifs (1). All Cbl proteins have a highly conserved N-terminal tyrosine kinase-binding (TKB) domain that mediates interactions between Cbl proteins and phosphorylated tyrosine residues on Cbl substrates. C-terminal to the RING finger, Cbl proteins have proline-rich domains that mediate interactions with SH3 domain-containing proteins. Phosphorylated tyrosine residues mediate interactions with SH2 domain-containing proteins such as the p85 subunit of PI3K. These protein-protein interaction motifs allow Cbl family proteins to function as |
| Immunogen | Immunogen: Recombinant protein of human CBLB Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [Cbl-b; RNF56; Nbla00127] |
| Gene, Accession # | [CBLB], Gene ID: 868, NCBI: NP_001308717.1, UniProt: Q13191 |
| Catalog # | MBS8502778 |
| Price | $310 |
| Order / More Info | CBLB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Schmidt, M.H. and Dikic, I. (2005) Nat Rev Mol Cell Biol 6, 907-18. 2. Naramura, M. et al. (2002) Nat Immunol 3, 1192-9. 3. Chiang, Y.J. et al. (2000) Nature 403, 216-20. 4. Fang, D. and Liu, Y.C. (2001) Nat Immunol 2, 870-5. 5. Heissmeyer, V. et al. (2004) Nat Immunol 5, 255-65. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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