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Antigenic Specificity | MSH2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MSH2 protein. The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-a dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-a is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in t |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human MSH2. |
Other Names | [MSH2; COCA1; FCC1; HNPCC; HNPCC1] |
Gene, Accession # | [MSH2], Gene ID: 4436, NCBI: NP_000242.1, UniProt: P43246 |
Catalog # | MBS9406527 |
Price | $255 |
Order / More Info | MSH2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |