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Antigenic Specificity | CALCOCO2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Xenophagy-specific receptor required for autophagy-mediated intracellular bacteria degradation. Acts as an effector protein of galectin-sensed membrane damage that restricts the proliferation of infecting pathogens such as Salmonella typhimurium upon entry into the cytosol by targeting LGALS8-associated bacteria for autophagy (PubMed:22246324). Initially orchestrates bacteria targeting to autophagosomes and subsequently ensures pathogen degradation by regulating pathogen-containing autophagosome maturation (PubMed:23022382, PubMed:25771791). Bacteria targeting to autophagosomes relies on its interaction with MAP1LC3A, MAP1LC3B and/or GABARAPL2, whereas regulation of pathogen-containing autophagosome maturation requires the interaction with |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 137-446 of human CALCOCO2 (NP 005822.1). |
Other Names | [NDP52] |
Gene, Accession # | [CALCOCO2], Gene ID: 10241, NCBI: NP_001248319, UniProt: Q13137 |
Catalog # | MBS8546765 |
Price | $280 |
Order / More Info | CALCOCO2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |