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Antigenic Specificity | UCHL3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: UCHL3 antibody detects endogenous levels of total UCHL3. Function: Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3, and exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ |
Immunogen | Immunogen: A synthesized peptide derived from human UCHL3 Subcellular Location: Cytoplasm. Tissue Specificity: Highly expressed in heart, skeletal muscle, and testis. |
Other Names | [Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin thioesterase L3; Ubiquitin thiolesterase; Ubiquitin thiolesterase L3; UCH L3; UCH-L3; UCHL3; UCHL3_HUMAN] |
Gene, Accession # | [UCHL3], Gene ID: 7347, NCBI: NP_001257881.1, UniProt: P15374 |
Catalog # | MBS9604431 |
Price | $240, $280 |
Order / More Info | UCHL3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |