Edit |   |
---|---|
Antigenic Specificity | Myelin Protein Zero Picoband |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Myelin protein zero (P0, MPZ) is a glycoprotein which in humans is encoded by the MPZ gene. This gene is specifically expressed in Schwann cells of the peripheral nervous system and encodes a type I transmembrane glycoprotein that is a major structural protein of the peripheral myelin sheath. The encoded protein contains a large hydrophobic extracellular domain and a smaller basic intracellular domain, which are essential for the formation and stabilization of the multilamellar structure of the compact myelin. Mutations in this gene are associated with autosomal dominant form of Charcot-Marie-Tooth disease type 1 (CMT1B) and other polyneuropathies, such as Dejerine-Sottas syndrome (DSS) and congenital hypomyelinating neuropathy |
Immunogen | Immunogen: E Coli-derived human Myelin Protein Zero recombinant protein (Position: I30-R153). Subcellular Localization: Cell membrane; Single-pass type I membrane protein. Cell membrane. Tissue Specificity: Found only in peripheral nervous system Schwann cells. |
Other Names | [Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero; MPZ] |
Gene, Accession # | [MPZ], Gene ID: 4359, NCBI: NP_000521.2, UniProt: P25189 |
Catalog # | MBS1750537 |
Price | $280 |
Order / More Info | Myelin Protein Zero Picoband Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |