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Antigenic Specificity | Phospho-MAP2K3-S189 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAPK/JNK. Phosphorylation of p38 MAP kinase dramatically stimulates its ability to phosphorylate protein substrates such as ATF-2 and Elk-1. MKK3 and MKK6 are both activated by different forms of cellular stress and inflammatory cytokines (4,5). Activation of MKK3 and MKK6 occurs through phosphorylation of Ser189 and Thr193 on MKK3 (2) and Ser207 and Thr211 on MKK6 (4,5). |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S189 of human MAP2K3 |
Other Names | [Phospho-MAP2K3-S189: MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2], [MAP2K3; MAP2K3; MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2; MEK3; MKK3; PRKMK3; SKK2; MAP kinase kinase 3; MAPKK 3; MEK 3; SAPK kinase 2; SAPKK-2; SAPKK2] |
Gene, Accession # | [MAP2K3], Gene ID: 5606, NCBI: P46734.2, UniProt: P46734 |
Catalog # | MBS125716 |
Price | $235, $350, $525 |
Order / More Info | Phospho-MAP2K3-S189 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |