Phospho-IR (Tyr1361) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-IR (Tyr1361) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-IR (Tyr1361) antibody detects endogenous levels of IR only when phosphorylated at Tyrosine 1361. Description: After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake.Function: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins th |
| Immunogen | Immunogen: A synthesized peptide derived from human IR around the phosphorylation site of Tyrosine 1361 Subcellular Location: Membrane; Single-Pass Type I Membrane Protein. Tissue Specificity: Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocyt |
| Other Names | [CD220; HHF5; HIR B; INSR; Insulin receptor; Insulin receptor subunit beta; IR] |
| Gene, Accession # | [IR], Gene ID: 3643, NCBI: NP_000199.2, UniProt: P06213 |
| Catalog # | MBS9600871 |
| Price | $240, $280 |
| Order / More Info | Phospho-IR (Tyr1361) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Geng S, Zhu W, Wang S, Xie C, Li X, Wu J, Li Y, Chen Y, Wang X, Meng Y, Zhang Q, Chen J, Zhong C; Journal: Biochem Biophys Res Commun. P53 modulates hepatic insulin sensitivity through NF-kB and p38/ERK MAPK pathways. Geng S, Wang S, Zhu W, Xie C, Li X, Wu J, Zhu J, Jiang Y, Yang X, Li Y, Chen Y, Wang X, Meng Y, Zhong C; Journal: Biomed Pharmacother. Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells. Geng S, Wang S, Zhu W, Xie C, Li X, Wu J, Zhu J, Jiang Y, Yang X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Zhong C; Journal: Toxicol Lett. Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways. |
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MYBIOSOURCE INC.
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