PLAU Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PLAU |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The human urokinase-type plasminogen activator receptor (uPAR) is a 55-65 kDa, highly glycosylated, GPI-anchored cell surface receptor (the deglycosylated protein is 35 kDa) (1-3). It is a central player in the plasminogen activation pathway. uPAR binds with high affinity to a serine protease urokinase-type plasminogen activator (uPA) and converts plasminogen to its active form plasmin in a spatially restricted manner on the cell surface (4). Plasmin further carries out the activation of uPA, which is inhibited by serpins, such as plasminogen activator inhibitors (5). Therefore, uPAR plays a key role in regulating extracellular proteolysis. In addition, uPAR plays an important role in regulating cell proliferation, adhesion, and mobility (6 |
| Immunogen | Immunogen: Recombinant protein of human PLAU Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [ATF; UPA; URK; u-PA] |
| Gene, Accession # | [PLAU], Gene ID: 5328, NCBI: NP_001138503.1, UniProt: P00749 |
| Catalog # | MBS8503992 |
| Price | $310 |
| Order / More Info | PLAU Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nielsen, L.S. et al. (1988) J Biol Chem 263, 2358-63. 2. Behrendt, N. et al. (1990) J Biol Chem 265, 6453-60. 3. Roldan, A.L. et al. (1990) EMBO J 9, 467-74. 4. Ellis, V. et al. (1991) J Biol Chem 266, 12752-8. 5. Ellis, V. et al. (1990) J Biol Chem 265, 9904-8. 6. Liu, D. et al. (2002) Cancer Cell 1, 445-57. 7. Waltz, D.A. et al. (1997) J Clin Invest 100, 58-67. 8. Blasi, F. and Sidenius, N. (2010) FEBS Lett 584, 1923-30. 9. Mazar, A.P. et al. (2011) Curr Pharm Des 17, 1970-8. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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