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Antigenic Specificity | LEPR |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:250 |
Immunogen | Immunogen: A synthetic peptide of human LEPR |
Other Names | [OBR; OB-R; CD295; LEP-R; LEPRD] |
Gene, Accession # | [LEPR], Gene ID: 3953, NCBI: NP_001003679.1, UniProt: P48357 |
Catalog # | MBS8545121 |
Price | $280 |
Order / More Info | LEPR Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |