Edit |   |
---|---|
Antigenic Specificity | MAPKAP1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total MAPKAP1 polyclonal antibody. Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of |
Immunogen | Immunogen: Recombinant Human Target of rapamycin complex 2 subunit MAPKAP1 protein (1-290aa) |
Other Names | [TORC2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; Stress-activated map kinase-interacting protein 1; SAPK-interacting protein 1; mSIN1; MAPKAP1; MIP1; SIN1] |
Gene, Accession # | [MAPKAP1], Gene ID: 79109, NCBI: NP_001006618.1, UniProt: Q9BPZ7 |
Catalog # | MBS9416079 |
Price | $320 |
Order / More Info | MAPKAP1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |