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Antigenic Specificity | ITGA5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 750-1000 of human ITGA5 (NP 002196.4). |
Other Names | [FNRA; CD49e; VLA-5; VLA5A] |
Gene, Accession # | [ITGA5], NCBI: NP_002196.2, UniProt: P08648 |
Catalog # | MBS8545948 |
Price | $280 |
Order / More Info | ITGA5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |