Edit |   |
---|---|
Antigenic Specificity | COPS3 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: COPS3 antibody detects endogenous levels of total COPS3. COPS3 Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. |
Immunogen | Immunogen: A synthesized peptide derived from human COPS3 |
Other Names | [COP9 complex subunit 3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 signalosome complex subunit 3; COPS3; CSN3; JAB1-containing signalosome subunit 3; SGN3; Signalosome subunit 3] |
Gene, Accession # | [COPS3], Gene ID: 8533, NCBI: NP_001186054.1, UniProt: Q9UNS2 |
Catalog # | MBS8510682 |
Price | $290 |
Order / More Info | COPS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |