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Antigenic Specificity | RAF-1 (Phospho Ser259) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat, monkey |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-Raf-1 (S259) Polyclonal Antibody detects endogenous levels of Raf-1 protein only when phosphorylated at S259. Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk)and Raf-1. Raf-1 is a cytoplasmic protein with intrinsic serine/threonine activity. It is broadly expressed in nearly all cell lines tested to date and is the cellular homolog of v-Raf, the product of the transforming gene of the 3611 strain of murine sarcoma virus. The unregulated kinase activity of the v-Raf protein has been associated with transformation and mitogenesis while the activity of Raf-1 is normally suppressed by a regulatory N-termin |
Immunogen | Immunogen: Synthesized peptide derived from human Raf-1 around the phosphorylation site of S259 |
Other Names | [Rabbit Raf-1 (phospho Ser259); RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1] |
Gene, Accession # | [RAF-1], Gene ID: 5894, NCBI: NP_002871.1, UniProt: P04049 |
Catalog # | MBS9701150 |
Price | $130, $220, $325 |
Order / More Info | RAF-1 (Phospho Ser259) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |