Cbl (C14) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Cbl (C14) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse, rat, and human Cbl, reactive with normal and rearanged forms of Cbl. The proto-oncogene c-Cbl was initially identified as the cellular homologue of v-Cbl oncogene that induces pre-B cell lymphomas and myeloid leukemias in mice (1&2). In more recent studies Cbl has been shown to be a negative regulator of tyrosine kinase signaling (2-4). The ubiquitin ligase activity of Cbl leads to the degradation of tyrosine kinases, thus attenuating the signal of receptors (3&4). Targets of Cbl include activated protein tyrosine kinases belonging to the Src and Syk/Zap-70 families (3). An additional mechanism to attenuate receptor signaling is thought to be achieved by Cbl's interaction with downstream targets of tyrosine kinases, such |
| Immunogen | Immunogen: Synthetic peptide mapping to the carboxy terminal domain of human Cbl p120. |
| Other Names | [cbl; CG7037-PA, isoform A; CG7037 gene product from transcript CG7037-RB; CG7037-PA; CG7037-PB; Cbl; Cbl-PA; Cbl-PB; D-cblLONG; D-cblSHORT; cable; CG7037-PA, isoform A], [Cbl; Cbl; anon-WO0118547.68; cbl; CBL; CG7037; CG7043; d-cbl; D-cbl; D-Cbl; D-Cbl L; D-cblL; D-cblS; dCbl; Dcbl; DCbl; DmelCG7037; Dv-cbl; Dv-Cbl; F165; v-Cbl] |
| Gene, Accession # | [Cbl], Gene ID: 38961, NCBI: CAA11149.1, UniProt: O46034 |
| Catalog # | MBS440060 |
| Price | $240 |
| Order / More Info | Cbl (C14) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Liu YC, Altman A. 1998. Cbl: complex formation and functional implications. Cell Signal 10(6):377-385. 2. Miyake S, Lupher ML, Andoniou CE, Lill NL, Ota S, Douillard P, Rao N, Band H. 1997. The Cbl protooncogen product: from an enigmatic oncogene to center stage of signal transduction. Crit Rev Oncog 8(2-3):189-218.3. Rao N, Dodge I, Band H. 2002. The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J Leukoc Biol 71(5):753-763.4. Sanjay A, Horne WC, Baron R. 2001. The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinase. Sci STKE 2001(110):PE40. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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