Human Interleukin-1 receptor-associated kinase 4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Interleukin-1 receptor-associated kinase 4 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | antigen affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | n/a |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/T |
| Immunogen | Immunogen: Recombinant human Interleukin-1 receptor-associated kinase 4 protein (1-220aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34469 / sc-34470 / sc-99154 |
| Other Names | [IRAK-4; Renal carcinoma antigen NY-REN-64; IRAK4], [IRAK4; IRAK4; IPD1; REN64; IRAK-4; NY-REN-64; IRAK-4] |
| Gene, Accession # | [IRAK4], Gene ID: 51135, NCBI: NP_001107654.1, UniProt: Q9NWZ3 |
| Catalog # | MBS1497754 |
| Price | $120, $160 |
| Order / More Info | Human Interleukin-1 receptor-associated kinase 4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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