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Antigenic Specificity | JNK1/JNK2/JNK3 (phospho-Thr183/Tyr185) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of JNK1/JNK2/JNK3 only when phosphorylated at Thr183/Tyr185. Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T(p)-P-Y(p)- V - V) derived from Human JNK1/JNK2/JNK3. |
Other Names | [Stress-activated protein kinase JNK1; c-Jun N-terminal kinase 1; JNK-46] |
Gene, Accession # | [JNK1/JNK2/JNK3], Gene ID: 5599, NCBI: NP_001265476.1, UniProt: P45983 |
Catalog # | MBS9409478 |
Price | $200, $255 |
Order / More Info | JNK1/JNK2/JNK3 (phospho-Thr183/Tyr185) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |