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Antigenic Specificity | NDP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction. |
Immunogen | Immunogen: Recombinant Human Norrin protein (25-133AA) |
Other Names | [Norrin; Norrie disease protein; X-linked exudative vitreoretinopathy 2 protein; NDP; EVR2] |
Gene, Accession # | [NDP], Gene ID: 4693, NCBI: NP_000257.1, UniProt: Q00604 |
Catalog # | MBS7105009 |
Price | $160, $235 |
Order / More Info | NDP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |