Beclin-1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Beclin-1 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Beclin-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions (1). One of the proteins critical to this process is Beclin-1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30 (2). Beclin-1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells (3). Mammalian Beclin-1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL but not with Bax or Bak (4). While Beclin-1 is generally ubiquitously expressed, it is monoallelically deleted in 40-75% of sporadic huma |
| Immunogen | Immunogen: Recombinant protein of human Beclin-1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [ATG6; VPS30; beclin1] |
| Gene, Accession # | [BECN1], Gene ID: 8678, NCBI: NP_001300927.1, UniProt: Q14457 |
| Catalog # | MBS8527336 |
| Price | $310 |
| Order / More Info | Beclin-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21. 2. Kametaka, S. et al. (1998) J Biol Chem 273, 22284-91. 3. Liang, X.H. et al. (1999) Nature 402, 672-6. 4. Liang, X.H. et al. (1998) J Virol 72, 8586-96. 5. Aita, V.M. et al. (1999) Genomics 59, 59-65. 6. Liang, X.H. et al. (2001) Cancer Res 61, 3443-9. 7. Yue, Z. et al. (2003) Proc Natl Acad Sci U S A 100, 15077-82. |
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