PDZD3 (Center), 258-285 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | PDZD3 (Center), 258-285 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3. Guanylyl cyclase C (GCC, or GUCY2C; MIM 601330) producescGMP following the binding of either endogenous ligands orheat-stable enterotoxins secreted by E. coli and other entericbacteria. Activation of GCC initiates a signaling cascade thatleads to phosphorylation of the cystic fibrosis transmembraneconductance regulator (CFTR; MIM 602421), followed by a net effluxof ions and water into the intestinal lumen. IKEPP is a regulatoryprotein that associates with GCC and regulates the amount of cGMPproduced following receptor stimulation (Scott et al., 200 |
| Immunogen | n/a |
| Other Names | [Na(+)/H(+) exchange regulatory cofactor NHE-RF4; NHERF-4; Intestinal and kidney-enriched PDZ protein; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4; PDZD3; IKEPP; NHERF4; PDZK2] |
| Gene, Accession # | [PDZD3], Gene ID: 79849, NCBI: NP_001161940.1, UniProt: Q86UT5 |
| Catalog # | MBS9201635 |
| Price | $165, $370 |
| Order / More Info | PDZD3 (Center), 258-285 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Zachos, N.C., et al. Cell. Physiol. Biochem. 22 (5-6), 693-704 (2008) : Kato, Y., et al. Mol. Pharmacol. 67(3):734-743(2005) Hegedus, T., et al. Biochem. Biophys. Res. Commun. 302(3):454-461(2003) Scott, R.O., et al. J. Biol. Chem. 277(25):22934-22941(2002) |
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MYBIOSOURCE INC.
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