Edit |   |
Antigenic Specificity | PTOV1 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | rat. predicted to work with: human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Rabbit IgG polyclonal antibody for Prostate tumor-overexpressed gene 1 protein(PTOV1) detection. Tested with WB in Human;Rat. Background: Prostate tumor overexpressed gene 1 protein is a protein that in humans is encoded by the PTOV1 gene. It is mapped to 19q13.33. This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human PTOV1 (385-414aa NFVNGIRRVIANQQQVLQRNLEQEQQQRGM), different from the related mouse and rat sequences by one amino acid. Ig Type: Rabbit IgG |
Other Names | [Prostate tumor-overexpressed gene 1 protein; ACID2; Activator interaction domain containing protein 2; Gcap3; prostate tumor overexpressed 1; Prostate tumor overexpressed gene 1; PTOV 1; prostate tumor overexpressed 1], [PTOV1; PTOV1; ACID2; PTOV-1; ACID2; PTOV-1] |
Gene, Accession # | [PTOV1], Gene ID: 53635, NCBI: NP_001292034.1, UniProt: Q86YD1 |
Catalog # | MBS178055 |
Price | $280 |
Order / More Info | PTOV1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Entrez Gene: PTOV1 prostate tumor overexpressed gene 1. 2. Santamaria A, Castellanos E, Gomez V, Benedit P, Renau-Piqueras J, Morote J, Reventos J, Thomson TM, Paciucci R (Feb 2005). PTOV1 enables the nuclear translocation and mitogenic activity of flotillin-1, a major protein of lipid rafts. Mol Cell Biol 25 (5): 1900-11. 3. Santamaria A, Fernandez PL, Farre X, Benedit P, Reventos J, Morote J, Paciucci R, Thomson TM (Feb 2003).PTOV-1, a novel protein overexpressed in prostate cancer, shuttles between the cytoplasm and the nucleus and promotes entry into the S phase of the cell division cycle. Am J Pathol 162 (3): 897-905. |