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Antigenic Specificity | TRIM13 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. |
Immunogen | Immunogen: Recombinant human E3 ubiquitin-protein ligase TRIM13 protein (40-310AA) |
Other Names | [E3 ubiquitin-protein ligase TRIM13; B-cell chronic lymphocytic leukemia tumor suppressor Leu5; Leukemia-associated protein 5; Putative tumor suppressor RFP2; RING finger protein 77; Ret finger protein 2; Tripartite motif-containing protein 13; TRIM13; LEU5; RFP2; RNF77] |
Gene, Accession # | [TRIM13], Gene ID: 10206, NCBI: NP_001007279.1, UniProt: O60858 |
Catalog # | MBS7044410 |
Price | $120, $160 |
Order / More Info | TRIM13 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |