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Antigenic Specificity | ECD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.6 mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total ECD protein. Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May pla |
Immunogen | Immunogen: Fusion protein of human ECD Immunogen Type: Peptide |
Other Names | [GCR2; SGT1; HSGT1] |
Gene, Accession # | [ECD], Gene ID: 11319, NCBI: NP_001129224.1, UniProt: O95905 |
Catalog # | MBS9430296 |
Price | $255 |
Order / More Info | ECD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |