Paxillin (Thr-538), Phospho-Specific Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Paxillin (Thr-538), Phospho-Specific |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, rat, mouse, chicken, frog |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This antibody detects a 68kDa* protein corresponding to the molecular mass of paxillin on SDS-PAGE immunoblots of A431 cells treated with calyculin A. This reactivity is not observed after lambda phosphatase treatment. Paxillin, a focal adhesion protein, is involved in focal adhesion formation during cell adhesion and migration. Paxillin contains LD motifs, LIM domains, and SH3-/SH2-binding domains that participate in a variety of protein-protein interactions with kinases, GTPase-activating proteins, and cytoskeletal proteins. Phosphorylation of paxillin occurs at tyrosine, threonine, and serine sites. Serine and threonine phosphorylation of paxillin occur in response to growth-factor activation, PKC activators, and fibronectins. Phosphoryl |
| Immunogen | Immunogen: Phospho-Paxillin (Thr-538) synthetic peptide (coupled to KLH) corresponding to amino acid residues around threonine 538 from human paxillin a. This sequence is highly conserved in rat and mouse paxillin and is also found in the other paxillin isoforms (b & g). |
| Other Names | [paxillin isoform 2; Paxillin; paxillin; paxillin], [PXN; PXN] |
| Gene, Accession # | Gene ID: 5829, NCBI: NP_001074324.1, UniProt: P49023 |
| Catalog # | MBS474131 |
| Price | $385 |
| Order / More Info | Paxillin (Thr-538), Phospho-Specific Antibody from MYBIOSOURCE INC. |
| Product Specific References | Wu, D. W. et al. (2014) Oncogene 33(35): 4385. Huang, C. et al. (2003) Nature 424:219-223.Woodrow, M.A. (2003) Exp. Cell. Res. 287(2):325-338.Ishibe, S. et al. (2004) Mol. Cell 16 :257-267.Romanova, L.Y. et al. (2010) J Cell Sci. 123:1567-1577. |
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MYBIOSOURCE INC.
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