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Antigenic Specificity | TNFSF11 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene |
Immunogen | Immunogen: Recombinant protein of human TNFSF11 Observed Molecular Weight: 35kDa |
Other Names | [ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2] |
Gene, Accession # | [TNFSF11], Gene ID: 8600, NCBI: O14788.1 |
Catalog # | MBS2520042 |
Price | $150, $225, $360 |
Order / More Info | TNFSF11 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |