CD47 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-CD47 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | CD47 |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Clone ANC2F6 binds to an epitope within the extracellular Ig-like domain of human CD47. Human CD47 (IAP, Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular c-terminal domain. It interacts with it ligand SIRP alpha (CD172a, Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPa axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC(2), Glioma(3) and Breast Cancer(4) |
| Immunogen | n/a |
| Other Names | [Human CD47; IAP; Integrin Associated Protein], [CD47; CD47; IAP; OA3; MER6; MER6; IAP] |
| Gene, Accession # | [CD47], Gene ID: 961, NCBI: CEJ95640.1 |
| Catalog # | MBS666928 |
| Price | $270 |
| Order / More Info | CD47 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1) Xiaojuan Liu, Yang-xin Fu, et al. (2017) J Hematol Oncol 10:12. doi:10.1186/s13045-016-0381-z PMID: 28077173. 2) Wu L, Sun ZJ, et al. (2018) Oncoimmunology 7(4): e1397248. Doi: 10.1080/2162402X.2017.1397248. 3) Lif F, Jiang X, et al. (2017) Oncoimmunology 7(2): e1391973. doi: 10.1080/2162402X.2017.1391973. 4) Norman MZ, Janji B, et al. (2018) Oncoimmunology. 7(4):e1345415. doi: 10.1080/2162402X.2017.1345415. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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