Edit |   |
Antigenic Specificity | RNF19A (Center), 384-413 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: mouse, porcine) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A. The protein encoded this gene contains two RING-fingermotifs and an IBR (in between RING fingers) motif. This protein isan E3 ubiquintin ligase that is localized in Lewy bodies (LBs), acharacteristic neuronal inclusion in Parkinson's disease (PD)brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,but not other ubiquitin-conjugating enzymes. This protein is foundto bind and ubiquitylate synphilin 1 (SNCAIP), which is ainteracting protein of alpha synuclein in neurons, and a majorcomponent of LB. Alternatively spliced transcript varia |
Immunogen | n/a |
Other Names | [E3 ubiquitin-protein ligase RNF19A; 632-; Double ring-finger protein; Dorfin; RING finger protein 19A; p38; RNF19A; RNF19] |
Gene, Accession # | [RNF19A], Gene ID: 25897, NCBI: NP_001267468.1, UniProt: Q9NV58 |
Catalog # | MBS9212163 |
Price | $165, $370 |
Order / More Info | RNF19A (Center), 384-413 Antibody from MYBIOSOURCE INC. |
Product Specific References | Huh, J.W., et al. Gene 424 (1-2), 63-70 (2008) : Matsuoka, S., et al. Science 316(5828):1160-1166(2007) Ishigaki, S., et al. Neurobiol. Dis. 25(2):331-341(2007) Huang, Y., et al. J. Biol. Chem. 281(17):11610-11617(2006) Ishigaki, S., et al. J. Biol. Chem. 279(49):51376-51385(2004) |