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Antigenic Specificity | GITRL |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The tumor necrosis factor (TNF) and TNF receptor (TNFR) gene superfamilies regulate numerous biological functions including cell proliferation, differentiation, and survival through regulating the activation of the transcription factor NF-kB and various mitogen-activated protein kinases. The glucocorticoid-induced tumor necrosis factor receptor (GITR) is an emerging member of this family that is expressed on CD4+ CD25+ regulatory T cells and appears to have crucial immune regulation functions. Its ligand GITRL is expressed in endothelial and antigen-presenting cells and can activate NF-kB, induce both pro- and anti-apoptotic effects, inhibit the suppressive activity of regulatory T cells, and co-stimulate responder T cells through GITR. Dom |
Immunogen | Immunogen Type: Recombinant protein Immunogen Description: Raised against purified recombinant human GITR ligand. |
Other Names | [AITRL] |
Gene, Accession # | [GITRL], Gene ID: 8995, NCBI: NP_005083.2, UniProt: Q9UNG2 |
Catalog # | MBS9407349 |
Price | $320 |
Order / More Info | GITRL Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |