phospho CREB1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | phospho CREB1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.1 mg, 0.2 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The ATF/CREB family consists of transcription factors that function through binding to the cAMP responsive element (CRE) palindromic octanucleotide, TGACCTCA. The best characterized members of this gene family include CREB-1, CREB-2, ATF-1,ATF- 2,ATF-3and ATF-4. these transcription factors share highly-related COOH terminal leucine zipper demerization and basic DNA bindings but are highly divergent in their amino terminal domains. Although each of the ATF/CREB proteins bind CREs in their homodimeric form, in cerain instances they also bind as heterodimers, both within the ATF/CREB family and with members of the AP-1 transcription factor family. It has recentlybeen shown that protein kinase A- mediated CREB phosphorylation results in its bin |
| Immunogen | Source Note: Polyclonal p-CREB-1 antibody was produced from sera of mice immunized with synthetic protein containing residues surrounding ser133. |
| Other Names | [Rabbit phospo CREB1 purified; ser133; creb1; creb-1;], [CREB-1] |
| Gene, Accession # | [CREB1], Gene ID: 1385, NCBI: NP_004370.1, UniProt: P16220 |
| Catalog # | MBS551068 |
| Price | $280, $385 |
| Order / More Info | phospho CREB1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • CREB-1 is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation.Mol. Cell. Biol., Apr 2008; 28: 2446 - 2459. • il-10 regulation by hiv-tat in primary human monocytic cells: involvement of calmodulin/calmodulin-dependent protein kinase-activated p38 mapk and sp-1 and CREB-1 transcription factors.J. Immunol., Jan 2007; 178: 798 - 807. • intracellular hiv-tat expression induces il-10 synthesis by the CREB-1 transcription factor through ser133 phosphorylation and its regulation by the erk1/2 mapk in human monocytic cells.J. Biol. Chem., Oct 2006; 281: 31647 - 31658. • requirement of smad3 and CREB-1 in mediating transforming growth factor- (tgf) induction of tgf3 secretion.J. Biol. Chem., Oct 2006; 281: 29479 - 29490. • impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene.Mol. Pharmacol., Dec 2004; 66: 1536 - 1543. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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